As Head of Bioscience Metabolism for Cardiovascular, Renal and Metabolism (CVRM), I oversee and guide our strategy, seeking to understand the role of metabolism in illness. This includes participating in the core strategy team and business development activities, and being a champion for inclusion and diversity.  

Altered metabolic processes play a key part in all CVRM diseases and understanding these changes can be critical in finding effective treatments. My role involves working closely with teams across all of our research sites and CVRM research programmes. We have a diverse research portfolio, spanning from target investigations to phase 2b studies in diseases such as diabetes, obesity, non-alcoholic liver diseases and dyslipidaemia (high lipids in the blood).

I received my PhD in Physiology and Pharmacology from the University of Nottingham Medical School and have worked for many years in the field of drug discovery including work on muscle disorders, obesity and diabetes, and using both in vivo and in vitro methods. I have been working consistently across CVRM diseases since 2014.

Effective teamworking is vital to successful drug development. It is important that colleagues can benefit from a range of skills, communicate effectively and understand each other. My experience in collaborative team building and leadership extends across academia and industry, including both scientific leadership and people development. The collaborations I facilitate enable teams across the business and beyond to generate high-impact science that drives the discovery of life-changing medicines.


Science is at the forefront of our decision-making and I am proud to work for a company that champions scientists, supporting cross-industry collaboration to drive innovation. It is incredibly rewarding to mentor research rising stars, providing them with the opportunity to grow, succeed, and ultimately, transform outcomes for patients.

David Baker Executive Director, Head of Bioscience Metabolism, Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca
David Baker, Head of Metabolism Bioscience, CVRM.

CURRENT ROLE

Executive Director, Head of Bioscience Metabolism, Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca

2019 – present

Executive Director – Head of Metabolism Bioscience Department Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca, leading the metabolism disease area strategy across a portfolio from target discovery to phase 2b in diabetes

2017 – 2019

Director of Research – Cardiovascular, Renal and Metabolism (CVRM) MedImmune, led a portfolio of 16 metabolic disease and chronic kidney disease projects, delivering progress through governance, scientific excellence and drug discovery direction

2014 – 2017

Principal Scientist – Cardiovascular and Metabolic Diseases (CVMD), Head of UK CVMD In Vivo Core Team, MedImmune. Established an internal in vivo pharmacology capability and recruited talented in vivo and in vitro scientists to deliver key data for T2D, CKD and NASH projects

2012 – 2014

Associate Director of Pharmacology – Global In Vivo Lead, Safety Pharmacology, AstraZeneca. Delivered in vivo cardiovascular, renal, respiratory and gastrointestinal safety pharmacology regulatory and investigational studies to all iMED projects in the global portfolio

2009 – 2012

Team Leader/Associate Principal Scientist, In Vivo Disease Models Group, CVGI, Diabetes and Obesity Bioscience, AstraZeneca. Led a team of 10 scientists and defined the global in vivo strategy for alignment of in vivo models to disease target product profiles, outlining responsibilities from pre-clinical to clinical and translational science

Scientific publications

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes.

Nag A, Dhindsa R, Mitchell J, et al. Science Advances, 2022, Nov 8(46)

Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

Ouberai MM, Gomes Dos Santos AL, Kinna S, et al. Nat Commun 8, 1026 (2017)

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

Lewis JE, Woodward OR, Nuzzaci D et al. Mol Metab. 2022 Dec. 66: 101604


Veeva ID: Z4-52290
Date of preparation: February 2023