Kenny Hansson
As Head of Bioscience for Cardiovascular in CVRM 我负责澳门葡京赌博游戏的心力衰竭和心血管疾病的早期项目管道到候选药物投资决策, 澳门葡京赌博游戏如何决定将哪些候选药物用于进一步的早期临床开发. I support the preclinical bioscience aspects, e.g. 开发项目中药物的作用机制和药理学/疗效, from target identification to phase III. I encourage and support cross-disciplinary decision-making, as well as strategic external collaborations.
With over 20 years’ experience in the pharmaceutical industry, I have extensive expertise in bioscience, covering target identification and preclinical development, 一直到临床晚期和上市产品，心血管和 renal medicine. I have experience across many modalities and drug development projects, from small molecules, peptides, antibodies and proteins, to antisense oligonucleotides and messenger ribonucleic acid (mRNA).
I completed my PhD in Clinical Chemistry at Linköping University, Sweden, 专注于实时分析与血液凝固和纤溶相关的过程，使用新的光学和流变传感技术来诊断止血疾病.
我的兴趣和科学经验涵盖了包括心血管疾病在内的各个领域, anaemia and kidney disease, wound healing and tissue regeneration, plus thrombosis and haemostasis. I have worked on biosensor technologies, including surface plasmon resonance, quartz crystal microbalance and free oscillation rheometry. I have also supported patents, 包括使用FII和纤维蛋白原治疗止血疾病, 基于mRNA的治疗方法在心力衰竭和糖尿病足溃疡愈合中的制定和使用.
澳门葡京赌博游戏在心血管领域的抱负是使受损组织再生，并最终治愈心脏病, as well as finding ways to prevent these illnesses. The key areas in heart failure 我在澳门葡京网赌游戏专注于加强的是扩张型心肌病和保留射血分数(HFpEF)的心力衰竭, 以及研究与心肌病和心力衰竭有关的磷蛋白和SERCA蛋白.
2019 CEO Award
PHB Award 2014
Key Achievements
2020 – present
2019 – 2020
2018 - 2019
Scientific publications
用VHH体内阻断磷蛋白可增强心力衰竭时的收缩性和舒张性
De Genst E, Foo K S, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad T R S, Louch W E, Pehrsson S, Park A, Ikeda Y, Li X, Mayr L M, Wickson K, Jennbacken K, Hansson K, Fritsche-Danielson R, Hunt J and Chien K R. Nature Communications (2022) 13, 3018,
磷蛋白反义寡核苷酸改善小鼠心肌病心功能
Beverborg N G, Später D, Knöll R, Hidalgo A, Yeh S T, Elbeck Z, Silljé H H W, Eijgenraam T R, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes M F, Cornelis J. Boogerd 6, Michael Frisk 7, Eva van Rooij 6, Sagar Damle4, Louch W E, Wang Q-D, Fritsche-Danielson R, Chien K R, Hansson K M, Mullick A E, de Boer R A, van der Meer P
Nature Communications (2021) 12, 5180
Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation
Eijgenraam T R, Stege N M, Teixeira V O N, de Brouwer R, Schouten E M, Beverborg N G, Sun L, Später D, Knöll R, Hansson K M， Amilon C, janz
J. Mol. Sci. (2022) 23, 2427
修饰的VEGF-A mRNA诱导持续的多方面微血管反应并加速糖尿病伤口愈合.
Sun N, Ning B, Hansson K M, Bruce A, et al. Scientific Reports 2018, 8:17509 DOI: 10.1038/s41598-018-35570-6
数学模型预测糖尿病伤口愈合加速依赖于VEGF-A mRNA的空间分布(AZD8601)
Rikard S M, Myers P J, Almquist J, Gennemark P, Bruce A C Gberg M, Fritsche-Danielson R， Hansson K M, Lazzara M J and Peirce S M.
Cellular and Molecular Bioengineering (2021) 14, 321-338
基于模型的分析揭示VEGF-A mRNA (AZD8601)持续和剂量依赖性加速伤口愈合
Joachim Almquist, Michaela Rikard, Maria Wågberg, Anthony C. Bruce, Peter Gennemark, Regina Fritsche-Danielson, Kenneth R. Chien, Shayn M. Peirce, Kenny Hansson* and Anna Lundahl*.
*Shared senior authorship
CPT Pharmacometrics Syst. Pharmacol. (2020) 9, 384–394
重组人凝血酶原(MEDI8111)联合纤维蛋白原剂量依赖性地改善了稀释型凝血病伴不受控制出血的猪模型的生存时间并减少了失血量
Hansson K M, Pehrsson S, Johansson K J, Lindblom A, Nelander K, Lövgren A. Blood Coagulation and Fibrinolysis 2019, 30:140–148
Veeva ID: Z4-53355
Date of preparation: April 2023